Chemoprevention of N-Methylnitrosourea-induced Colon Carcinogenesis by Ursodeoxycholic Acid-5-aminosalicylic Acid Conjugate in F344 Rats
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Inhibitory Effects of Chlorogenic Acid on Azoxymethane-induced Colon Carcinogenesis in Male F344 Rats.
Modifying effects of chlorogenic acid (CA) on carcinogen-induced large bowel carcinogenesis was examined in rats. A total of 150 male F344 rats, 4 weeks old, were divided into 5 groups. At 6 weeks of age, groups 1-3 were given subcutaneous injections of AOM (15 mg/kg body weight) once a week for three weeks. Group 2 was given the diet mixed with CA at the dose of 250 ppm during the initiation p...
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The effect of dietary undegraded carrageenan (Viscarin 402) on colon carcinogenesis was studied in female inbred F344 rats. Weanling rats were fed semipurified diets containing 0 or 15% undegraded carrageenan. At 7 weeks of age, all animals except controls were given azoxymethane (AOM) s.c. at a dose rate of 8 mg/kg body weight per week for 10 weeks or methylnitrosourea (MNU) intrarectally at a...
متن کاملChemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid.
The present studies were conducted at the Universities of Chicago and Arizona to examine and compare the effects of supplemental dietary ursodeoxycholic acid to cholic acid, a known tumor promoter, and to piroxicam, a known chemopreventive agent, in the azoxymethane (AOM) model of experimental colonic carcinogenesis. Male Fischer 344 rats were utilized in these experiments. All animals were fed...
متن کاملChemoprevention of colon carcinogenesis by dietary organoselenium, benzylselenocyanate, in F344 rats.
The effect of feeding benzylselenocyanate (BSC) and its sulfur analogue, benzylthiocyanate (BTC), 2 wk before, during, and until 1 wk after carcinogen administration (initiation phase) on intestinal carcinogenesis induced by azoxymethane (CAS:25843-45-2) was studied in male F344 rats. Weanling rats were raised on a semipurified diet (AIN-76A diet; control diet). Beginning at 5 wk of age, groups...
متن کاملChemoprevention of azoxymethane-induced colon carcinogenesis by dietary feeding of S-methyl methane thiosulfonate in male F344 rats.
Modifying effects of dietary exposure of S-methyl methane thiosulfonate (MMTS) isolated from cauliflower Brassica oleracea L. var. botrytis on rat colon carcinogenesis induced by azoxymethane (AOM) and on the expression of cell proliferation biomarkers were investigated in two experiments. In experiment 1, male F344 rats were given three s.c. injections of AOM (15 mg/kg body weight) and fed 100...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 2002
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.2002.tb01252.x